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Although the function of BTN1A1 is not fully understood, its expression profile suggests an important role in lactation [39].
While the physiological roles of HIC are not yet well understood, its expression, like that of its Xenopus ortholog XIC, appears to be under tight control [42], [48] (Q. Wang et al., unpublished results).
Although the precise mechanism remains poorly understood, its expression is independent of APC mutation.
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A more in-depth analysis of semigamy is necessary to understand its expression and regulation at the genetic and molecular level.
Although the mechanism of increased TF expression occurrence in cancer is still not completely understood, its increasing expression on the cancer cell surface as the disease progresses may be mainly related to an active unmasking procedure linked to altered glycosylation mechanisms [ 56].
To better understand its ubiquitous expression in the skin, FLG2 mRNA expression was further investigated in cultured keratinocytes derived from human foreskin.
But to integrate protein expression into systems biology, scientists need to better understand its relationship to gene expression.
A candidate microRNA, miR-638, was further studied in human lung fibroblasts derived from patients with severe COPD to better understand its role in regulating gene expression patterns associated with emphysema pathogenesis in vivo.
However, the role of c-Myb in mammopoeisis and breast tumorigenesis is poorly understood, despite its high expression in the majority of breast cancer cases (60 80%).
The identification of a distant transcriptional enhancer of the gene SPRR1A within the 5-Mb epidermal differentiation complex (EDC) on 1q21 was an important finding to understand the control of its expression in keratinocytes in vitro and in vivo [66].
The mechanisms controlling AQP5 expression are not very well understood, but expression of AQP5 has been correlated with methylation levels of its promoter, with a reduced expression when the promoter was highly methylated [ 11– 13].
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