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The region of raised calcium concentration within the nerve terminal is localized close to the active zones and, by a process that is not yet understood, causes vesicles in this region to fuse with the nerve terminal membrane and to open outward (exocytosis), thereby discharging their contents into the synaptic cleft.
Precautionary principles are the foundations for policy when it has to deal with weakly understood causes of potential catastrophic or irreversible events, and where protective decisions require certain and costly policy interventions that may not solve the problem that they are designed to correct.
Prevention of more recently understood causes, such as ascending in utero infection due to GBS, BV, or associated vaginal microflora, will require new care practice strategies including expanded screening and maternal vaccination.
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Complicating the recalls is the lack of a clearly understood cause of the airbag explosions.
Chronic inflammatory demyelinating polyradiculoneuropathy is an orphan disease of poorly understood cause.
This could assist diagnosis and may shed light on the, as yet, not understood cause of the disorder.
Intervertebral disc herniation is a widespread but poorly understood cause of back pain [ 6].
Sudden infant death syndrome (SIDS) is a poorly understood cause of infant death during the first year of life.
To understand causes and consequences of landscape change, it is often not enough to simply detect change.
People understand causes and transmission of infection.
It is a major challenge to understand causes and consequences of evolution of the phenotypes.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com