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Furthermore, the molecular mechanisms which discern between renal regeneration and chronic progressive fibrosis are still incompletely understood and insights derived from animal and cell culture studies have not yet been sufficiently translated into clinical context.
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Precision medicine allows a dramatic expansion of biological data, while there is still an urgent need to understand and insight the exact meaning of those data to human health and disease.
Once the data is understood and business insights can be harvested from the data, then scaling in various ways becomes the issue, then enterprise technology starts to play a role.
Despite its central role in genomic duplication, the molecular mechanism of primer synthesis by the Pol α/primase complex is poorly understood and structural insights remain limited.
The long term consequences of HS are poorly understood and deeper insight is required to find possible treatment strategies.
In spite of what we have achieved so far, a complete understanding of how cells interact with well-defined nanomaterial at the molecular level remains poorly understood and more insight need to be provided.
In particular, the mechanism of differentiation of cancers is incompletely understood and an insight into this process would undoubtedly lead to new therapeutic targets.
By dissecting each step, their eventual integration as a complex series of overlapping sub-behaviors can be understood, and provide insight into nervous system function.
The inversion is all the more touching, all the more upsetting, because – had Wilde understood and heeded the insights of his own story – he surely would not have delivered himself up to his own destruction with the reckless hypocrisy that he did.
Likewise, the precise regulation of key actin motility proteins during EMT and MET is only beginning to be understood and may provide insight that will be clinically useful.
The cellular and molecular aetiology of fatty degeneration is not fully understood, and gaining greater insight into the physiological processes that regulate muscle fibre atrophy, fibrosis and lipid accumulation will likely improve the treatment of patients with chronic rotator cuff tears.
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