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But since consciousness isn't understood, alterations to it aren't very well understood either.
Although the role of immune dysfunction in the pathogenesis of SSc is currently not well understood, alterations in cellular immunity are typified by aberrant T cell biology both in the skin as well as circulation of SSc patients.
Although the involvement of epigenetic marks in the OIS state remains poorly understood, alterations in the distribution of histone modifications were previously observed in OIS cells (Chicas et al., 2012; Shah et al., 2013).
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The most significant efforts to understand alterations produced by MECP2 deficiency have been concentrated in neurons and, more recently, in microglia and astrocytes [4 6].
This information is valuable to understand alteration of miRNA expression induced by ENU exposure.
Although the mechanistic basis for alterations in miRNA, especially in the context of cellular malfunction, is not well understood, such alterations play a pivotal role in pathological processes and have recently been proposed as biomarkers for brain neoplasms, degenerative diseases, autism, and schizophrenia [ 23– 25].
Although the precise functions of ether phospholipids are still poorly understood, significant alterations in their physiological levels are associated either to inherited disorders or to aggressive metastatic cancer.
With a virus such as WNV, where specific virulence factors are not completely understood and alterations in primary viremia could turn an asymptomatic infection into encephalitis, even subtle changes brought about by mosquito saliva at peripheral sites cannot be ignored.
Acquiring these traits can be conveniently described and understood as alterations in pathways.
It is well understood that alterations in the structure and capacity of the glomerulus influence the tubules.
However, the precise role of DNMT1 functions in cancer cells is less well understood, since alterations of this gene have not been reported for cancer [ 18].
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