Since the overall importance of the PI3K/Akt pathway to melanoma biology cannot be understated, these findings imply clinical significance of MIF signalling in this disease.
"This finding, understated in both the study's conclusion and in the press release, introduces a big note of caution.
The authors of the study cautioned that their findings have probably understated the problem -- and Freiberg pointed out a number of the study's blind spots in a 2013 response.
Considering that scrums occur relatively infrequently in comparison to tackles and rucks, 38 these findings are noticeably understated.
However, based on a critical examination of the literature in question, my conclusion is that the phenomenon has been exaggerated while the uncertainty surrounding the findings has been understated.
Although these findings have been understated in the literature, we suggest that they are likely more than just an epiphenomenon, and may be an important, global aspect of the complex circadian orchestration of animal genomes.
The importance of this finding cannot be understated and implies that large-scale networks of functional connectivity that are interrogated with task-based fMRI paradigms are the same networks interrogated during fMRI paradigms that do not have a specific task (that is, rs-fMRI).
Referred to by some scientists as the "differential susceptibility hypothesis" or journalist David Dobbs as "The Orchid Hypothesis", these findings shouldn't be understated.
Some of the companies disputed the findings, saying that the study understated their tax payments by omitting deferred taxes that they may pay in future years.
"While the revised results are not as inaccurate as the original findings, driver earnings are still understated," says Lyft's director of communications, Adrian Durbin.
Job-finding and job-separation rates are understated by one third, while the transitions in and out of inactivity have an even larger bias.
