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This study provides valuable information about the role of applied loading on proteoglycan segregation, which should aid in tissue engineering applications and for understanding valve biology and pathology.
Subsequently, we discuss the implications of this closed-loop perspective on the effects of valve dynamics in closed-loop systems for understanding valve behavior compensation techniques and developing new ones.
The purpose of this study is to describe the current knowledge of the regulation of the valvular "response to injury" process, since we feel that this paradigm is essential to understanding valve disease.
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Identification ECM components that can regulate VIC phenotype and function has significant implications for understanding native valve disease, investigating possible treatments, and designing new biomaterials for valve tissue engineering.
This is crucial in understanding what Valve represents.
To gain a better understanding of valve formation in amniotes and zebrafish, it will be important to investigate the cellular processes that are regulated by these signalling pathways.
Current understanding of aortic valve geometry provides good models for aortic leaflet design, and pericardial leaflet construction is illustrated in this article for bicuspid and tri-leaflet valves.
Increased understanding of tricuspid valve coaptation and the effects of pathological and repair conditions may be useful to inform future repair design.
Advances in understanding dynamic mitral valve function have led to a repair technique with no leaflet resection, accurate dynamic annular and chordal sizing, and preservation of left ventricular outflow tract dynamics.
Thus, zebrafish models have the potential to contribute to our understanding of cardiac valve development and pathology.
We next wanted to examine how loss of Rock signalling in NCC affects the expression of factors known to be important in NCC behaviour in the outflow tract, as a way of better understanding why the valve patterning anomalies arise.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com