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Understanding this difficulty requires an appreciation of how Notch is activated: binding of DLL1 or Jag1 ligands to the Notch extra-cellular domain triggers a conformational change that exposes a β-strand of Notch to cleavage by ADAM family metalloproteases [41], [42].
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No child reported difficulty understanding this term.
Patients in this sample, however, had difficulty understanding this concept.
Secondly, even though we adopted the DSHEA definition of herbs, some patients had difficulty understanding this definition.
Furthermore, the term 'standard drink' is not a term commonly used in Russia; therefore, the respondents may have had difficulty understanding this concept.
For example, the "road rage" was seldom used in China, many patients had difficulty understanding this phrase, and then we discussed how to express it more clearly and more comprehensible.
For each questionnaire item, a series of clarifying questions were asked: "Did you have any difficulty understanding this item?"; "What does it mean to you?"; "Is the item relevant to you?"; "Are any words difficult to understand?"; "Would you use any other words?"; and "Are the response options appropriate?".
Unfortunately, studies conducted over the past 25 years have indicated that students have a number of difficulties understanding this concept (Bishop and Anderson 1990; Gregory 2009; Nehm et al. 2009; Shtulman 2006).
However, a serious difficulty in understanding this teaching arose among Hōnen's following, one Hōnen struggled to deal with but was unable to resolve doctrinally.
However, because of the way in which the word "bioenergy" is used in the media as well as in research, the public is bound to have difficulty in understanding this concept.
The difficulty in understanding this hierarchy comes at the fourth stage, where it is not clear exactly what moral factor is added to the preceding three stages.[49] At the beginning of his Nicomachean Ethics, Aristotle remarked that "the good is that at which all things aim".
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