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Therefore, identifying the effector molecules and/or signal transduction pathways that regulate the carcinogenesis and malignant development is crucial for understanding the vulnerabilities of osteosarcoma and for isolating molecular targets that may disrupt the tumor machinery whereas protecting the integrity and function of normal tissue.
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But attitudes are now changing, and there has been a recent rise in interest in the application of evolutionary biology to understanding the vulnerability of individuals and populations toward disease.
Having experienced a significant decline in rainfall since the late 1960s, the Sudano-Sahelian region represents an important case for understanding the vulnerability of pastoral and agro-pastoral peoples to recurrent drought.
1 Qualitative approaches to understanding the vulnerability of FSWs have looked upon integrated structural intervention strategies to reduce vulnerability among FSWs.
Hence, understanding the vulnerability of island species to a lack of functional redundancy is complicated, but important, to ensure that functional ecosystems are maintained.
Identification of hydrogeologic and anthropogenic variables associated with the occurrence of an individual VOC, when coupled with the knowledge of the behavior and fate of the compound, can aid in understanding the vulnerability of aquifers to VOC contamination.
There is a category of software that's become general cyber risk assessment, understanding the shared vulnerabilities of companies and creating a risk score.
Similarly, cities need to focus not only on understanding what climate projections suggest for the city, but also on understanding the current vulnerabilities of people, infrastructure and systems that keep the city running, and project how these may change over time.
This could be important for understanding the selective vulnerability of motor neurons, and possibly other affected neuronal types in ALS-FTLD, especially as expression of Met-TDP-35 can kill motor neurons.
We distinguish 'threat' from 'risk', as the latter incorporates an understanding of the vulnerabilities of the communities, and probabilities associated with the hazard, which is beyond the scope of this paper.
More sophisticated poverty analysis and understanding of the vulnerabilities of many children (developmental, psychological and practical), which has occurred within the CARI initiative has led the discussion to move from a somewhat finite response to the problems of children orphaned by HIV to a greater understanding of the varied reasons that may render a child vulnerable.
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