These results may help in the design of β2AR-targeting drugs with improved efficacy, as well as in understanding the receptor subtype selectivity of ligand binding in the β family of the adrenergic receptors that share almost identical ligand-binding pockets, but show notable amino acid sequence divergence in the putative ligand-entry site, including ECL2 and the extracellular end of TM7.
Findings for ponderosa pine forest (PPF) differed among three forest subtypes (dry, mesic, and moist PPF), indicating that understanding the ecology of PPF subtypes is essential for development of ecologically based management practices.
This study is preceded by a significant body of research on GEP of lymphoma that has focused on understanding the pathogenesis of individual subtypes of lymphoma and refining the diagnosis and prognosis of these subtypes.
These results suggest that large gaps still exist in the transcriptomic study of specific clinical subtypes as well in the generation of the transcriptional profile of well-studied clinical subtypes; understanding the complex landscape of prematurity will require large-scale, systematic genome-wide analyses of human gestational tissues on both understudied and well-studied subtypes alike.
Accordingly, future studies to map TDLUs for histopathological and molecular characterization may have value for understanding the pathogenesis of different subtypes of breast cancer and achieving translational goals.
Since the majority of human tumors are of the luminal subtype, understanding the cell of origin of these tumors and how they relate to other tumor subtypes will impact cancer therapy.
Understanding the contribution of each subtype of glutamate receptors, and related downstream signaling pathways may provide a new opportunity to design better medicine for the treatment of different forms of chronic pain.
The fundamental key for successful management of rosacea is based on identification of the specific subtype, understanding the severity of presentation, and tailoring treatments to best suit the expectations of the patient.
In the context of a diverse HIV-1 genome, understanding the role of infecting subtype on disease progression is essential to guide public health policy, plan regionally appropriate HIV care and treatment programs, and define appropriate populations and endpoints for HIV prevention efficacy trials.
Nevertheless, our results suggest that specific molecular expression patterns, in addition to others previously defined for myositis, might provide insight into classifying and understanding the pathophysiology of these different subtypes of myositis.
