DOI: http://dx.doi.org/10.7554/eLife.00184.013 The structure of GsuK provides an excellent model system for understanding the structural basis of multi-ligand regulation of the RCK gating ring as commonly seen in the eukaryotic Slo channels.
The overall results of the present studies provide a basis for understanding the structure and properties of these polymers in terms of intermolecular interactions and also have implications for the processing of the polymers for diverse applications.
This analysis provides a basis for understanding the structure and content of the workshops along with participant responses to the events, the challenges of connecting women from diverse cultures and geographic areas, and the ways forward for the project.
Recent advances in understanding the structure of nicotinic acetylcholine receptors.
Understanding the structure of stories is important.
In Stuart Schreiber's laboratory Rosen worked in understanding the molecular basis of receptor-ligand interactions by studying the structure and function of immunophilin FKBP12, which binds the immunosuppressant FK506 protein.
Detailed inspection of the structure of kurtoxin offers the possibility of understanding the molecular basis of its Cav3 (T-type) Ca2+ channel selectivity and could facilitate clarification of the gating mechanism of voltage-gated ion channels.
Understanding the molecular basis of their anticancer properties based on structure and activity is important for the rational design of novel chemotherapeutic agent [ 37].
The structure determination of this peptide agonist is important in understanding the molecular basis of peptide ligand recognition by the receptor and for rational drug design.
It is now established that understanding the molecular basis of biological function requires atomic resolution maps of both structure and dynamics.
