The reviewers are in agreement that this paper has the potential represent an important contribution to understanding the specification and patterning of the dorsal-ventral (aboral-oral) axis of the sea urchin embryo.
Understanding the architectural specification of a system is important to avoid the proliferation of violations [11].
Understanding the regional specification of the neurons derived from pluripotent stem cells may facilitate their integration and aid the design of effective strategies for neural transplantation within the CNS.
Hence, there is an increased emphasis on understanding the genetic specification of these cells, not least because the adult CNS contains a large pool of apparently dormant oligodendrocyte progenitors, which could, in principle, be recruited to repair demyelinated lesions.
It is also important to take into account additional transcription factors that lie downstream of both Nk×2.1 and Lh×6 so as to obtain a better understanding of the specification of MGE-derived interneurons.
An important clue toward understanding the mechanism of vertebrate retinal fate specification was the discovery of Math5 (atoh7), a proneural basic-loop-helix (bHLH) transcription factor that is evolutionarily related to Drosophila Atonal and mouse Math1 (Atoh1) [7], [7].
The understanding of episodic memory requires the specification of neural mechanisms involved in forming memory representations when an irrelevant distractor interferes with encoding of the target.
The specification of new autoantibodies could help in understanding the pathophysiology of SSc.
The specification of new autoantibodies could help in understanding the pathophysiology of SSc and reveal new diagnostic and/or prognostic markers.
ES cells provide an essential model for understanding the role of TGF- β signaling in lineage specification and differentiation.
