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Functional profiling methods exploit different definitions of modules in an attempt of understanding the functional basis of high-throughput experimental results [7].
In the meantime, understanding the functional basis of the disease risk variants so far identified presents an outstanding challenge.
These results provide promising targets for future experimental investigation as well as potential clues for understanding the functional basis of lifespan extension in mammalian systems.
Understanding the functional basis for genetic variants associated with human complex traits is, therefore, critical for understanding the underlying biological processes.
The set of longevity-associated genes identified in this analysis therefore provides well-supported targets for future experimental investigation as well as potential clues for understanding the functional basis of lifespan extension in mammalian systems.
Identification of differences in gene expression between genders in tissues that are important in the response to and metabolism of pharmaceuticals or environmentally relevant chemicals will be useful for understanding the functional basis of gender differences in the pharmacology and toxicology of these compounds.
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Our analysis of AP13 drought responses therefore establishes a foundation for understanding the functional genomic basis of drought responses in the most widely studied accession of P. virgatum and more broadly in other C4 grasses.
Understanding the functional genetic basis of stress tolerance in rye will facilitate the improvement of stress tolerance in wheat (Triticum aestivum L). and barley (Hordeum vulgare L).
Our findings have theoretical implications for understanding the functional significance of neural entrainment and the functional basis of individual differences in rhythm perception and sensorimotor synchronization skills.
The identified biological processes and signalling pathways collectively targeted by co-expressed miRNAs in CRC provide a basis for understanding the functional role of miRNAs in cancer.
Analysis of the bestrophins from a phylogenetic perspective may provide the basis for understanding the functional diversity within this conserved protein family.
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