Broad screening and bioinformatics/chemoinformatics have been applied to understanding off-target effects of GPCR ligands.
A wide spectrum of therapeutic and technological needs drives efforts to capture liver physiology and pathophysiology in vitro, ranging from prediction of metabolism and toxicity of small molecule drugs, to understanding off-target effects of proteins, nucleic acid therapies, and targeted therapeutics, to serving as disease models for drug development.
Motivation: Analysis of relationships of drug structure to biological response is key to understanding off-target and unexpected drug effects, and for developing hypotheses on how to tailor drug therapies.
10.38am: Blair says he has an understanding of off-the-record briefings.
He also had a nuanced understanding of off-field duties, right down to putting on monster masks with Laura at Halloween and visiting Yorktown's boosters.
The U.S. Environmental Protection Agency has begun to evaluate residential exposures to agricultural pesticides from spray drift and volatilization (U.S. EPA 2014), and there is a growing understanding of off-target drift for each active ingredient.
He said Navratilova taught him the importance of understanding the off-court personality of tennis partners.
Understanding trade-offs in coastal zone planning and management requires a systematic inventory of the full range of ecosystem services, including cultural services.
We describe how to incorporate uncertainty into the estimation of utility thresholds, demonstrate how utility thresholds can be translated into empirically-tractable metrics, and highlight the value of utility thresholds for understanding trade-offs among management objectives within an EBM context.
Understanding trade-offs between clonal and sexual reproduction, and how they are influenced by dispersal, is important for evaluating the survival probability of clonally reproducing SI species and their future invasion potential [ 13, 17].
Understanding what sets off these stronger-than-normal reactions, what their root cause is, can help you understand yourself better.
