In any case, the identification of two novel splice variants may have implications for our understanding of TRAIL-mediated apoptosis in neoplastic and non-neoplastic human cells.
Hence, understanding the regulation of TRAIL receptor activation could provide insight into increasing TRAIL-induced apoptosis in these TRAIL-resistant cells.
Accordingly, the understanding of the mechanism of TRAIL resistance is the key to resolve primary obstacles in TRAIL mediated gene therapy approach.
These data are critical to analysis and interpretation of clinical trial data involving rTRAIL and TRAIL receptor agonist antibodies in OSCC patients, as well as the understanding of the role of TRAIL and its receptors during oral carcinogenesis.
Thus, understanding the exact molecular determinants of TRAIL resistance and developing strategies to overcome such resistance without killing normal cells are extremely important prerequisites for the successful deployment of TRAIL as a therapeutic agent.
Thus, understanding PMN production, localization, and release of TRAIL is important in the design of future BCG-based bladder tumor immunotherapy protocols.
Owing to its novel activity, withanolide E is a promising reagent for the analysis of mechanisms of TRAIL resistance, for understanding HSP90 function, and for further therapeutic development.
Perhaps a set of fuzzy breasts sprouting from my chest, or some semblance of emotional intelligence, or at least a clearer understanding of how cereal, salad, and trail mix can be feminine.
Therefore, the identification of tumor features predicting the response of cancer cells to TRAIL, the understanding of the mechanisms orchestrating the outcome and the characterization of molecular targets that will improve the initial apoptotic response are important goals to achieve.
