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A more complete understanding of these pathways can therefore be useful in developing therapies or medical devices to correct such deficits.
We outline the cellular biology that is regulated by these DUBs and E3s and highlight how the inhibitory compounds have improved our understanding of these pathways.
Here we describe how the Xenopus egg extract system, in combination with specifically designed DNA templates, contributed to our detailed understanding of these pathways.
Finally, we discuss how the understanding of these pathways can help to design therapeutics for specific targeting of breast cancer tumors.
Understanding of these pathways enables different fruitful approaches like phytoremediation and biofortification.
It is hoped that an understanding of these pathways may provide clues to novel targets that may be amenable to the drug-discovery process.
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The increasing clinical exploration of agents that induce ER stress and apoptosis in myeloma cells, such as proteasome or NEDDylation inhibitors, HSP90 inhibitors and histone deacteylase inhibitors, underscores the importance of furthering our understanding of how these pathways may be manipulated to achieve maximal cytotoxic effects in malignant plasma cells.
In recent years, a better understanding of these deregulated pathways (e.g., the EGFR pathway) led to the development of therapeutic strategies, which have been employed with some success in CRC patients.
However, current understanding of how these pathways are activated in the context of developmental programming remains poorly defined.
The successful development of agonist/antagonist of the PTH and Wnt signaling pathways are profits of the understanding of these key pathways.
Also essential is an understanding of how these pathways draw on host metabolism and what impact this has on cell growth.
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