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In all, our studies successfully extend our understanding of the switch mechanism beyond the apoptosis decision and provide insights into pharmacological manipulation of Bcl-2 family members as further cancer therapies.
This switch in coreceptor usage is associated with a worsened prognosis which makes a better understanding of the switch dynamics of direct clinical importance.
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But a recent study by Abbey shows our fears are driven by myth and a poor understanding of the switching process.
Its clarification will be beneficial to get a comprehensive understanding of the switching mechanisms.
It is suggested that further study is needed for the understanding of the switching mechanism.
Our work is of great significance on the deep understanding of the switching mechanism and the improvement of the uniformity of RRAM devices.
However, the poor understanding of the switching reliability, mechanism, low-current operation (<100 μA) are the bottlenecks in its further development and optimization.
Therefore, a better understanding of the switching mechanism based on the formation and dissolution of the Cu or Ag filament in solid electrolytes is required for future applications.
It is expected that the CBRAM device can be mass productive in the near future, if there is a solution of reliability under few microampere operation and a clear understanding of the switching mechanism.
The temperature dependence results demonstrate that the N-SET1 behavior is dominated by Cu conductive filament (CF) reformation caused by the Cu CF overgrowth phenomenon while the N-SET2 is related to the formation of oxygen vacancy CF. This work may provide a comprehensive understanding of the switching mechanism in oxide-based ECM devices.
By perturbing key feedback components connected to the central p53-Mdm2 loop and examining how the threshold, quantitative characteristics, and single-cell variability of the p53 bimodal switch are altered, a more quantitative understanding of the bimodal switch will be acquired.
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