Decades of research have given scientists a good understanding of the pathways that transmit input from the outside world to our brains – as long as we smell, hear or taste that information.
Therefore, an enhanced understanding of the pathways that contribute to β-cell failure is imperative.
Underlying mechanisms are still under debate and better understanding of the pathways involved may contribute to more targeted treatment strategies.
Improved understanding of the pathways and influences that control aquatic-to-terrestrial contaminant transport will be critical for effective risk management and remediation.
Several important advances have been made in our understanding of the pathways that lead to cell dysfunction and death in Parkinson's disease and Huntington's disease.
Further understanding of the pathways, mechanisms and consequences of M. tuberculosis dissemination could have a major impact in designing novel vaccines and therapeutic strategies.
More rigorous process (Roelen et al. 2017) and impact evaluations (Manley et al. 2012; Glassman et al. 2013), and causal and response analyses (Bailey and Hedlund 2012) are required to achieve a better understanding of the pathways.
However, due to modest improvements in overall survival, it is important to consider other strategies such as proteomics and/or phosphoproteomics to illuminate our understanding of the pathways that drive this disease.
Shared common activities between these assays can enhance our understanding of the pathways of interactions especially when it is difficult to infer an explicit relationship between the biological targets (e.g. lacking protein protein interaction or lacking sequence similarity).
Recent developments in our understanding of the pathways of immunity required to produce protection against different infections, allow immunological principles to be incorporated into the design new and better vaccines.
However, efforts to quantitatively link epidemiological, biomechanical loading, soft tissue tolerance, and psychosocial studies should be pursued to establish a better understanding of the pathways of injury and resultant preventive strategies.
