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Our current understanding of the initial pathogenetic steps in IgA nephropathy (IgAN) provides relatively limited rationale for immunosuppressive therapy.
This gap is detrimental to public health because an understanding of the initial stages of propagation is highly relevant for the overall disease epidemiology since it removes the perturbations produced by the appearance of an herd immunity on transmission intensity.
The difficulty in detecting rare infected cells immediately after mucosal HIV transmission has hindered our understanding of the initial cells targeted by the virus.
Our methodology, more generally, contributes to our understanding of the initial phases of developing learning technologies that are grounded in an understanding of learners' personal contexts.
Understanding of the initial stage of spray development is important in modelling of the injection process for optimisation of diesel engine design.
ERG photoresponse recordings constitute a simple, direct, and in vivo method to quantify rod and cone dysfunction for better understanding of the initial functional insult in human photoreceptor degenerations.
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There are still gaps in our understanding of both the initial triggers and the downstream modulators of ovarian development.
Better understanding of this initial damage and the SEC defence system is needed and might lead to new insights in the onset and, subsequently, the treatment of SOS.
GTAs decreased in perceptions of nervousness and increased in perceptions of understanding from the initial to final surveys.
Understanding the effect of the initial composition of a liquid feed on the spray drying process and morphology of powders is important in order to reduce the time and costs for process design, and ensure the desired properties of the final product.
This work therefore shows that a good understanding and control of the initial steps of the Er doping process is a key to the optimization of the whole process itself.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com