This understanding of the 'hygiene hypothesis' will open a new era of AD research.
Although the selection of test sets is often straightforward, the selection of appropriate control sets tends not to be and requires careful understanding of the competitive hypothesis tested in enrichment studies and consideration of the appropriate control set.
Finally, if our understanding of the hygiene hypothesis is to be translated into future therapies, these will largely need to be applied to patients in whom inflammatory diseases have already taken hold.
Next experiments will be focused on a better understanding of this hypothesis.
This recognition turned on a changed understanding of the "efficient market hypothesis," which held that securities prices in an efficient stock market were inherently unpredictable that is, an investment in the stock market was, for all but insider traders, equivalent to gambling in a casino.
My understanding of the translational selection hypothesis is that the major selection factor in protein sequence evolution is the minimization of misfolding burden, which is a combination of the proportion of proteins that need to be refolded or removed and of the actual toxicity to the cell of some of the misfolded variants.
Based on the understanding of the literature and the hypothesis reported in [ 9], we first model downstream regulation of Ras/MAPK cascades and succedent intracellular reactions induced by LIN-12/Notch signaling according to newly published literature.
The debate over adaptationism will continue to be important to philosophers of biology because much will be gained by a more informed understanding of the use of hypotheses about natural selection by biologists.
The sensitivity of newer technologies can have considerable clinical implications, underscoring the importance of gaining a better understanding of the plausibility of hypotheses such as sensitivities, over-diagnosis and initial difference in data from large scale trials such as the MLP.
That is a bold claim, so let me back it up: The scientific method boils down to using your intuition and understanding of the world to develop hypotheses and then rigorously testing these hypotheses against reality to determine if they are true or false.
