Sentence examples for understanding of the checkpoint from inspiring English sources
While loss-of-function alleles of Chk1 have been key to defining the role of Chk1 in the cellular response to DNA damage, it is clear that our understanding of the checkpoint response is far from complete.
However, understanding of the checkpoint between apoptosis and immune response in tumorigenesis is lacking.
By showing that Aurora B might contribute to checkpoint signalling independently of error correction, we provide the basis for a better molecular understanding of the checkpoint sensory apparatus.
The checkpoint elements of the kinetochore were originally revealed in a set of seminal budding yeast screens that gave rise to the mitotic arrest deficient (Mad 1, 2 and 3) and budding inhibited by benzimidazole (Bub1 and 3) genes that sparked the molecular understanding of the checkpoint (Hoyt et al, 1991; Li and Murray, 1991).
The demonstration of the failure of the indirect inhibition model in mammalian cells implies that while our intuition regarding the mechanism may be sound in principle, substituting in actual measurements reveals a significant gap in our quantitative understanding of the checkpoint.
The most different understanding of the first checkpoint is "pass through" link that is connected to the "Southern sky" concept and the "Sun" concept.
Understanding the topology of the checkpoint network that explains these results is the challenge for future studies.
The understanding of immune checkpoint molecules' co-expression in non small cell lung carcinoma (NCLC) is important to potentially design combinatorial immunotherapy approaches.
A better understanding of the molecular mechanisms underlying checkpoint blockade therapies will facilitate the design of novel strategies to treat and prevent resistance.
Importantly, by invoking a novel kinase as a central regulatory node, this study substantially develops our understanding of the poorly characterized abscission checkpoint.
A growing understanding of the biology of immune checkpoints and tumor immunology has led to the development of monoclonal antibodies designed to target co-stimulatory and co-inhibitory molecules in order to re-engage the immune system and restore antitumor immune responses.
