Sentence examples for understanding of specificity from inspiring English sources

Understanding the mechanism of action of a candidate therapeutic antibody against solid tumors requires a detailed physicochemical understanding of specificity and immune effector functions as well as the in vivo pharmacokinetics and biological activity in normal and tumor sites.

Application of this technique to this study is a first required step toward a more complete understanding of specificity in Gβγ signaling.

Beyond the detection of cross-reactivity targets to a given drug and the impact on the complete system, a full understanding of specificity and selectivity at the molecular level requires studying all macromolecules that are sharing the crowded (Ellis, 2001; McGuffee and Elcock, 2010; Minton, 1993) cellular milieu.

Medical screening is characterised not by success, but largely by a poor understanding of sensitivity, specificity, receiver-operator curves and lead-time bias... Prof Easton: @scubadoc - It is true that these measures, like sensitivity and specificity, are important measures to consider in deciding whether a screening programme is worthwhile.

The combination of these approaches also aids in the understanding of the specificity profiles of various PPIs.

Better understanding of this specificity depends on modelling studies based on ample structural and biochemical information.

An understanding of the specificity of targeting signal recognition leading to import requires an understanding of the receptor structures.

It also includes a holistic understanding of domain specificity in science, the role of social discourse and social certification in a scientific process, and ethics in science.

This chapter describes the crystal structures of farnesyltransferase (FTase) and their implications on the understanding of substrate specificity, mechanism, and inhibitor design.

For better understanding of its specificity, we have determined its residue preferences of 19 amino acids in six subsites (from P3 to P3′) as relative kcat/Km values (specificity constants).

Despite an abundance of powerful applications, the use of inteins is still hampered by limitations in our understanding of their specificity (defined as flanking sequences that permit splicing) and the challenge of inserting inteins into target proteins.