Sentence examples for understanding of selectivity from inspiring English sources

Adopting the high-throughput TEL-JAK Ba/F3 pSTAT5 cell assay suite in lead development paradigms should provide a more meaningful understanding of selectivity and facilitate the development of more selective JAK inhibitors.

Current crystal structures of the lysine riboswitch do not provide a complete understanding of selectivity as recognition is substantially mediated through main‐chain atoms of the amino acid.

This reaction network allows us to rationalize some experimental findings, and more importantly, provides clues on the understanding of selectivity and deactivation.

Density functional theory (DFT) calculations were performed and were in agreement with experimental observations providing the foundation for understanding of the selectivity for Ac and lanthanides on different DGA (diglycolamide) based resins.

Mechanistic understanding of the selectivity, regulation and function of the m6A modification depends on a complete characterization of the methyltransferase complex.

The global gene array has shown that essentially all hypoxia-regulated genes are regulated by VHL in renal cancer contributing to an understanding of tissue selectivity of transformation.

In the future it may be possible to synthesize bimetallic nanoparticles of particular structures based on a first-principles understanding of catalytic selectivity.

Therefore, being able to account for this destabilization in structural and dynamics terms is critical for a mechanistic understanding of base selectivity.

Hereby, we extend the simulations of β2AR in the empty form and bound to biased agonists by employing intensive conventional and accelerated MD simulations (cMD and aMD, respectively) to initiate understanding of functional selectivity at the molecular level.

Initial understanding of the selectivity of LY2784544 for JAK2 and JAK3 was determined in cell-based assays mediated either by homodimerization of erythropoietin receptors and resulting in recruitment and activation of JAK2 proteins, or heterodimerization of IL-2 receptors (subunits α, ß, and γ) and resulting activation of JAK1 and JAK3 proteins.

A better, research-based understanding of required selectivity over host kinases is therefore needed, and this may be best explored by focusing on short-term inhibition of the current set of "untouchable" kinase antitargets (i.e, a kinase antitarget that is linked to acute toxicity, or genotoxicity).