Sentence examples for understanding of receptor function from inspiring English sources

These include understanding of receptor function in selected cell-based backgrounds and early evaluation and validation of ex vivo observations in appropriate in vivo models.

However, our understanding of receptor function is largely based on biochemical ensemble measurements.

An understanding of the molecular basis of receptor function will greatly aid in the development of new molecules with high selectivity for the different subtypes of receptors, and will have potential therapeutic significance, not only for conditions as diverse as hypertension, diabetes insipidus and premature labor, but also in vasodilatory shock with organ dysfunction.

Traditional biochemical studies of receptor function have used site-directed or saturation mutagenesis to assess structure-function relationships for the role of individual amino acids in conserved protein domains, and such studies have been very useful towards our current understanding of protein function.

Here we provide a brief description of our understanding of opioid receptor function from both molecular and atomic perspectives, as well as their role in neural circuits in vivo.

Recent advances have improved our understanding of mGlu receptor function.

Certainly, this new information will accelerate our understanding of P2X receptor function and pharmacology at the atomic level.

Furthermore, a better understanding of P2X receptor function in simple invertebrate organisms may help shed new light on structure-function aspects of human P2X receptors in health and disease by virtue of conservation of functionally important amino acid residues between evolutionary remote P2X receptors and the identification of novel P2X mediated signalling pathways.

Novel strategies for mining of recognition specificities, combined with our recently increased understanding of immune receptor functioning, allows to increase and alter recognition specificities, which should ultimately increase the spectrum of recognition specificities that are available to control plant diseases in crops.

This is an important issue for better understanding potential chemokine/chemokine receptor function in the complex biologic processes that underlie the development and progression of osteosarcoma.

Due to these differences in receptor distribution, location and density it will be important to obtain a detailed understanding of receptor distributions in different areas and their specific role in cognitive functions.