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Our understanding of protein evolution would greatly benefit from mapping of binding landscapes, i.e., changes in protein-protein binding affinity due to all single mutations.
As pointed out by Hughes our understanding of protein evolution could be improved by studying specific well characterized systems [15].
Nonetheless, our analysis offers the first glimpse into genome level patterns of protein evolution and a step towards a more comprehensive understanding of protein evolution in insect vectors.
A complete understanding of protein evolution will require full characterization of the many factors that determine the selective forces acting on each amino acid of a protein.
Hence, the more we know about the genome complexity, the deeper we have the understanding of protein evolution.
If that's what the authors mean, they should say so, but it seems very far-fetched and marginally relevant to our understanding of protein evolution.
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Reviewer 2: Sandor Pongor - International Centre for Genetic Engineering and Biotechnology, Trieste, Italy There is mounting evidence in recent years that the study of post-translational modifications has important lessons for understanding diverse aspects of protein evolution.
Understanding the historical process of protein evolution begins with a phylogeny.
We are trying to tackle some of these issues that are central for a correct understanding of the genetic mechanisms of protein evolution using the ecdysone receptor.
Our results are important for a general understanding of the determinants of rates of protein evolution and the impact of selection on patterns of polymorphism and divergence.
Understanding the general rules governing the rate of protein evolution is fundamental to evolutionary biology.
More suggestions(15)
understanding of proteome evolution
understanding of protein activity
understanding of protein mobility
understanding of protein behavior
understanding of protein recognition
understanding of brain evolution
understanding of protein transport
understanding of warship evolution
understanding of protein synthesis
understanding of protein denaturation
understanding of intron evolution
understanding of protein folding
understanding of protein localization
understanding of protein stability
understanding of plastome evolution
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