Sentence examples for understanding of periostin function from inspiring English sources

This transcriptional variability could be important for a complete understanding of periostin function.

This paper provides evolutionary context for periostin's enigmatic C-terminal region and argues that it is likely key to a detailed understanding and disambiguation of periostin function, which is subject to some controversy in present literature.

Here we present the results of our computational analysis of periostin's C-terminal region (exons 16 - 23), which constitutes the most visible difference between periostin and its paralog TGFBI and is hence likely to be a major determinant of the functional differences between these two genes and of periostin function per se.

For further analysis of periostin function, periostin-deficient (Pn−/−) mice have been generated and well studied.

Finally, we propose the following tentative scheme of periostin function on the basement membrane of hair follicles: Periostin acts as a scaffold protein by binding to laminin γ2, fibronectin, and the proteinase BMP-1 to activate BMP-1 function for the cleavage of laminin γ2, which is followed by induction of keratinocyte proliferation through NF-κB phosphorylation.

Considering also that the functionally distinct periostin paralog TGFBI lacks an equivalent to periostin's C-terminal region, we propose that this region is of functional relevance, and that the sequence variation imparted by alternative splicing could be a modulator of periostin function.

A comprehensive understanding of periostin's functional spectrum is still actively developing, but certain core aspects emerging from those three major areas (skeletal development, heart development and disease, and cancer) are coming increasingly into focus.

It is hence not an exaggeration to expect that an improved understanding of periostin's C-terminal region in general and its alternative splicing patterns in particular may help resolve the sometimes controversial findings on periostin's biological effects.

Understanding of LTR structure increases understanding of LTR function, and of functional genomics.

Our results suggest that the delayed wound healing in the periostin−/− mice may have arisen from defective migration of myofibroblasts into the wound area, indicating the possibility of that periostin functions in myofibroblast migration and/or differentiation.

This development revolutionized the understanding of nervous function.