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Evolutionary optimization has been successfully used to increase our understanding of key properties of biochemical systems.
Physicochemical screens are increasingly used in drug discovery to provide an early understanding of key properties that affect ADME.
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Determination of key properties, including affinity, kinetics, specificity, ion dependence, and buffer sensitivity, is critical for understanding aptamer molecular recognition and implementing aptamers in diverse applications.
In the early 1980s the periodic trends of TMS catalysts on unsupported catalysts were discovered and these results formed the foundation for further basic understanding of the key properties that led to catalytic activity.
However, the failure mechanism under tensile loading has not been elucidated yet, despite its importance for the understanding of key mechanical properties of amyloid fibrils and plaques as well as the growth and aggregation of amyloids into long fibers and plaques.
Fully realizing this promise requires a greater understanding of key micro-biomechanical properties for each of the different skin layers – that are both the mechanical barriers and biological targets of these devices.
Understanding these key properties may lead to better therapeutic targeting.
Such approaches inform and refine the understanding of key events.
The mechanical properties of volcanic rocks at high temperatures and low pressures are key properties in the understanding of a range of volcanological problems, in particular lava flow dynamics.
Understanding of the properties over long time scales is a key requirement for the successful application of novel polymers as membrane materials.
Recent studies have led to significant advances in understanding the impact of key drug carrier properties such as size, surface chemistry and shape on their performance.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com