Our data suggest that m36 derivatives are promising HIV-1 candidate therapeutics and tools to study highly conserved gp120 structures with implications for understanding mechanisms of entry and design of vaccine immunogens and small-molecule inhibitors.
We hypothesize that in-depth understanding sites of entry and endosomal escape may lead to highly efficient nanotechnologies for drug delivery.
Our results not only expand the understanding of HCV entry, but also present a promising target for the invention of HCV entry inhibitor.
Many other targets in viral entry exist, and Connolly et al. further review advances in our structural and functional understanding of herpesvirus entry and the potential for targeting the process therapeutically.
The comparison of particle energy distributions from different altitudes in the cusp is important for developing our understanding of magnetospheric entry and energization processes.
Goal of the meeting was to discuss recent developments in the understanding of viral entry and dissemination at mucosal surfaces, rationale for designing vaccines to elicit mucosal immune responses by various routes of immunization, and the types of immune responses elicited.
This study increases our understanding of virus entry strategies and gives new insight into baculovirus-mediated gene delivery in human cells.
Predicting the evolutionary response to this rearrangement requires some understanding of genome entry mechanisms.
As result of these advances, recently, our understanding of viral entry, genomic replication and viral egress has improved.
Connolly et al. further review advances in our structural and functional understanding of herpesvirus entry and the potential for targeting the process therapeutically.
