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It thus paves the way towards a new level in understanding of cell physiology and pathophysiology of S. aureus and related pathogenic bacteria, opening new avenues for infection-related research on this crucial pathogen.
Mechanistic 'whole-cell' models are needed to develop a complete understanding of cell physiology.
Elementary mode analysis provides a rigorous basis to systematically characterize cellular phenotypes, metabolic flexibility and robustness which facilitates the understanding of cell physiology [ 39, 40].
Database URL: http://www.wholecellsimdb.org Source code repository URL: http://github.com/CovertLab/WholeCellSimDB Mechanistic 'whole-cell' models are essential for developing a complete understanding of cell physiology and enabling rational bioengineering and personalized medicine (1).
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A combination of experimental and ecological studies should discriminate between these alternative explanations and improve our understanding of this important aspect of cell physiology.
Understanding the molecular and cellular basis of cross-presentation will illuminate novel aspects of cell physiology and might lead to improved vaccine design.
The molecular mechanisms by which AQP2 interacts with many of these actin regulating proteins have yet to be investigated, but deeper understanding of the cell physiology of AQP2/actin associations might contribute to the development of new strategies for treatment of water balance disorders including nephrogenic diabetes insipidus (NDI) and congestive heart failure (CHF).
Since new therapeutic strategies could involve neutralization of virulence factors or direct elimination of S. aureus a better understanding of both cell physiology and pathophysiology is urgently required to successfully combat S. aureus infections.
With the publication of the genomic sequence and other relevant data sets for CHO cells since 2011, the doors have been opened for an improved understanding of CHO cell physiology and for the development of the necessary tools for novel engineering strategies.
A deeper understanding of HCRT cell physiology is required, including the identification of genes and proteins that may be the target of an autoimmune attack or may modulate hypocretin expression/metabolism to make this cell population more susceptible to potential apoptosis.
An in-depth understanding of IVD cell physiology is required for the design of novel regenerative therapies.
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