A complete and conclusive understanding of aromatase inhibition has remained elusive because of limited understanding of conformational changes of aromatase upon ligand binding and the effects of interactions with the active site and the heme iron on ligand affinities [26 28].
However, despite this evolving understanding, a key question has remained unanswered; what are the features of a pedestrian׳s balance response to base motion that gives rise to the self-excited force?
In spite of the deluge of images and narratives of Islam that has flooded the public space since September 11th, knowledge and understanding of the subject has remained limited.
Although a full understanding of cerebellar function has remained elusive, at least four principles have been identified as important: (1) feedforward processing, (2) divergence and convergence, (3) modularity, and (4) plasticity.
While the autoimmune pathophysiology of T1D has been established, a deeper understanding of this trigger has remained elusive.
Elucidating the molecular nature of the filopodial-tip complex is key for understanding filopodia functions, but has remained a mystery for over 30 years.
Its large size and modular structure have made molecular studies of this assembly challenging, and a comprehensive molecular understanding of the 40S⋅eIF3 interaction has remained elusive.
Despite major progress understanding bacterial cell division, it has remained unknown how Gram-negative bacteria coordinate OM invagination with IM invagination and septal synthesis.
Mr. Grammer grants that his technique has evolved, but he said that his understanding of the character's motivations has remained constant since those first episodes on "Cheers": "The first two choices that I made have been linchpins for the characterization.
In spite of several attempts, a fundamental understanding of how the catalyst works has remained unattainable.
