Exact(5)
Understanding downstream processes at the molecular level will help to develop and design peptides with increased activity.
Understanding downstream RAS-effectors that mediate oncogenesis in a RAS mutant setting will help tailor treatments that use RAS-effector inhibitors either alone or in combination to target RAS-driven tumors.
Understanding downstream effectors of oncogenic BRAF signalling may, therefore, facilitate the identification of novel therapeutic targets.
Although the signaling pathways initiating the AR are not completely understood, considerable progress in understanding downstream events has been made.
Reliance on uncontrolled cross-sectional studies with short follow-up periods particularly limits the potential for understanding downstream changes, such as body size, or how to prevent people from returning to old habits after financial incentives are withdrawn.
Similar(55)
Neurogeneticist Al La Spada of the University of Washington, Seattle, agrees that understanding the downstream effects of p53 will be very important.
Transcriptomic and proteomic studies not covered in this review are vital in understanding the downstream effect of gene mutations; and in identifying other mechanisms that promote cancer progression.
This in turn has become a limiting factor in the use and development of hMSC technologies as non-uniform sample variation impairs our understanding of downstream clinical efficacy.
Understanding the downstream effectors of lineage-specific programmes in melanoma will be crucial.
Understanding the downstream effect of MBD5 haploinsufficiency is another significant challenge.
Thus, as our understanding of downstream targets grows, so will our list of potential candidate genes for SLI.
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