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Emerging principles of SV40 assembly may help understanding assembly of other complex systems.
Given the vast number of Doc domains with predicteddual binding modes across multiple bacterial species, our approach opens up newpossibilities for understanding assembly and catalytic properties of a broadrange of multi-enzyme complexes.
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Although Algorithm 4 is not fast enough to solve the problem in a brain-sized neuronal network, it does offer a solution to the problem, permits us to analyze the structure of a given random graph and gain insight on understanding k-assemblies and cell assemblies.
The impact of these structural results towards understanding the assembly mechanism is discussed.
Our study provides a basis for understanding the assembly of mTORC2 and a framework to further characterize the regulatory mechanism of mTORC2 pathway.
It also comes with advanced features that try to make understanding the assembly code as easy as possible.
This is an important step toward understanding the assembly mechanism, architecture, and functional consequences of heteromer formation in ionotropic glutamate receptors.
With cancer parts lists in hand, new approaches to personalized medicine can be developed by understanding the assembly of cancer machines using modular domains in proteins and their associated networks.
The first piece of SYCE3 structural information provided insight into understanding CE assembly (Lu et al., 2014).
The higher resolution structure and biochemical analyses together provide a topological interpretation of human mTOR and relatively more accurate model for understanding the assembly and function of mTORC1.
"The work of Rakic and Jessell has provided, for the first time, a general framework for understanding the assembly of neural circuits within the mammalian brain," the Kavli foundation said in its commendation.
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