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Publication bias and the rarity of the diseases involved mean that international collaborations and sharing of data using clinical registries are essential for the clinical and academic communities to increase understanding and refine therapeutic protocols.

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A DSp provides the optimal region for systematic evaluation, mechanistic understanding and refining of a QbD approach.

Our experiences in developing these pilot films have been our 'laboratory' for understanding and refining the core features of Brokered Dialogue.

The current study investigates whether the gamma-band abnormalities seen in pASD in response to language stimuli are similar to those seen in ASD, with the goal of further understanding and refining the biomarker.

In the absence of a legal compulsion to respond to verbal autopsies (for example, as a condition of the issuance of a death certificate), one could anticipate that there would be challenges in achieving high response rates, and it is important that experiences in various settings is reported as a critical contribution to understanding of and refining verbal autopsy methods.

Hypothesis generation leads to system-wide questions and shows how to convert these questions to experimentally measurable quantities, such as changes in protein concentrations with chaperone or protease levels, which can then be used to improve our current understanding of proteostasis and refine the model.

Whether active or passive, information gathered throughout the iterative adaptive management cycle is used to increase ecological understanding, and adjust and refine management (Walters and Holling 1990).

Such a comparison would provide insight into the range of possible outcomes of managed gene flow and refine understanding on the optimal longevity of supportive breeding programs.

He added, "I think more than ever we need to follow a group of prodromal adolescents who get no drug treatment to see more clearly what happens and refine our understanding of what the prodrome is".

VENUS slides between us and the Sun today, an exceedingly rare spectacle that scientists hope will expand their understanding of our solar system and refine their inquiries about distant planets.

Surgeons and biomechanical engineers continue to debate and refine their understanding of these fundamental adaptations of UHMWPE for knee arthroplasty.

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