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As we engineer more biomimetic 3-D models we enhance our understanding and overcome current limitations, such as the use of cancer cell lines that form spheroids within a 3-D scaffold without a distinct stromal component [1].
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The concept of "cousins" is central to understanding and overcoming this particular obstacle to evolution education.
Other challenges include expanding the envelope of druggability for less tractable targets, understanding and overcoming drug resistance, and designing intelligent and effective drug combinations.
Meeting the global challenge to conserve biodiversity in intensively used agricultural landscapes is dependent on understanding and overcoming the limits to persistence of constituent species and ecological communities.
Watch above: This week on HuffPost Live, I spoke to Dr. Jeffrey Sachs about his recent blog post, "Understanding and Overcoming America's Plutocracy".
This fresh perspective may open up new avenues for understanding and overcoming these longstanding problems.
As this would severely limit the potential of L. lactis as an alternative expression platform for structural biology, we aimed at understanding and overcoming the bottlenecks limiting the functional expression of complex proteins upon growth in CDM.
Early experiments with plants highlighted the need for understanding and overcoming these technical limitations, while nonetheless establishing that near typical plant growth can occur in space.
Therefore DMD has emerged as a model genetic disorder for understanding and overcoming the challenges associated with developing personalised genetic medicines [ 2].
This model suggests that identification of biomarkers for cancer stem cells may help to identify the population of cells that resist chemotherapy and are metastatic with important implications for understanding and overcoming resistance to chemotherapies for human tumors.
Given the potential benefit of slowing the changes that lead to age-related diseases in humans, understanding and overcoming these side effects should be a high priority for future studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com