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The reversible regulation by Ub E3 and DUBs occurs at cell junctions, and has received increasing attention as a way to understand the modulation of barrier function in the context of diseases (Schaefer et al., 2012).
To better understand the modulation of stored word valence by speaker prosody, one may wish to examine the relationship between memory for prosody and word valence within a participant and within a given item.
27 These nonaligned observations require more study to really understand the modulation of the immune system in this patient population.
To better understand the modulation of miR-320b in tumorigenisis, we used an in vivo model to evaluate the effect of tumorigenicity after overexpression of miR-320b.
We here determine the effects of photodynamic treatment on transcriptional regulation and DNA binding of transcription factor AP-1 in order to understand the modulation of subsequent regulatory steps.
Therefore, further investigation is warranted to understand the modulation of the immune system by the combined effect of alcohol and burn that might result in dysregulation of adipose tissue and altered metabolism.
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It would be of interest to understand whether the modulation of HBHA expression by the bacilli during infection can induce this change in the host response and promote disease progression, as studies in animal models suggest [28] or whether the switch that we observed was an effect independent from the HBHA role in pathogenesis.
To understand whether the modulation of Aβ toxicity results from changes in the handling of the peptide, we western blotted SDS PAGE gels of brain homogenates using the 6E10 monoclonal antibody (Fig. 3A, representative of n = 3).
To begin to understand the selective modulation of PPARγ by TZDs in ovarian cancer cells, we examined the mRNA and protein expression profiles of PPARγ and the activation of PPARγ's promoter following TZD treatment.
To better understand the profound modulation of p38 MAPK activation elicited by MT2, we tested whether MKP-1, a phosphatase highly specific for p38 MAPK and also for JNK, could have a role in this setting, as previously observed.
Cyclophilin A is a prominent example of a cellular enzyme that enhances HCV replication by incompletely understood mechanisms, including the modulation of NS5B activity (Lohmann, 2013).
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