Sentence examples for understand the functional impact from inspiring English sources
In addition to the need for larger validation studies to confirm the observed associations, substantial additional research is needed to understand the functional impact of the various candidate polymorphisms on protein function and expression levels and how these functional changes contribute to alterations in ARDS outcomes.
More in vitro analyses are required to understand the functional impact of these genetic variations.
To understand the functional impact of arginine variants in EGFR, we analyzed the associated pathways and reactions in ProKinO.
Figure 4a provides example analysis results of how the BioMuta data can be used to better understand the functional impact of nsSNVs from different cancer types.
Despite important progress made in the field, several important questions remain to be addressed before we fully understand the functional impact of the interaction between inflammation and epigenome deregulation in liver tissue and define the precise underlying mechanisms.
Further studies in disease-relevant tissue types will be important to understand the functional impact of regulatory regions and specific Parkinson's disease-associated SNPs and its function in the disease process.
Additionally, the substrates of the NAGLU enzyme, including dermatan sulfate and heparan sulfate, are both positive in urine, further suggesting that loss of function mutations in NAGLU leads to abnormal accumulation of sulfate in urine, which may explain the observed neuropathy.> To further understand the functional impacts of the two variants, we attempted to examine structure models for NAGLU.
To understand further the functional impact of BTG3-AKT interaction, events that lie downstream of AKT activation such as AKT-GSK3β signaling were investigated.
To understand the functional and evolutionary impact of retroposition in the zebrafish genome, we screened the full genome of zebrafish for retrocopies and chimerical retrogenes.
However, since little is known about the interaction between leukemic blasts and their surrounding ECM, further studies are required to better understand the functional consequences and the impact of a dysregulation of the blast matrix interaction on the pathogenesis and the course of AML as well as the function of ITIH5 in this setting.
Our methodology and the high-confidence DDI predictions generated in this study can help to better understand the functional significance of PPIs at the modular level, thus can significantly impact further experimental investigations in systems biology research.
