Sentence examples for understand the functional effects from inspiring English sources

To understand the functional effects of the mutations, the variants were given a lethality score using CADD (Combined Annotation Dependent Depletion 29.

The purpose of this study was to further understand the functional effects of dopaminergic input to the dorsal striatum and to compare the effects of dopaminergic lesions in awake and anesthetized animals.

Also, experimental crossings Ma .balthica rubra individuals sampled on each side of the Brittany hybrid zone will help understand the functional effects of PCG divergence.

Advances in genotyping technology have provided us with a large number of genetic loci associated with cancer susceptibility; however, our ability to understand the functional effects of the genetic variants of these loci remains limited.

Our conclusions point to the necessity of taking a more function-centric perspective to understand the functional effect of CNAs, especially in the context of cancer.

This study was designed to identify significant differences in gene expression profiles of human papillomavirus (HPV ‐positive and HPV‐negative oropharyngeal squamous cell carcinomas (OPSCC) and to better understand the functional and biological effects of HPV infection in the premalignant pathway.

To understand the functional relevance of the induction of autophagy by IFNB1, we studied the biological effects of IFNB1 on MCF-7 cells.

The SNPs in the coding regions were analyzed to further understand the potential functional effects of the 7302R-specific SNPs.

Therefore, this functional effect annotation analysis here can be helpful to understand the dissimilarity among the functional effects of the four types of disease-associated variants.

Significant progress has been made in recent years, but the information available is insufficient to understand the mechanisms of the functional effects of most of the mutations associated with deafness [ 5, 14].

In order to understand the actual functional effect of the mtDNA mutations on susceptibility to cancer and tumorigenic process, functional analysis of mitochondrial bearing such mutations or polymorphisms in a transmitochondrial cybrid system will be necessary.