Sentence examples for understand the functional consequences from inspiring English sources

The goal of this study is to further understand the functional consequences of missense mutations in MSH2 on MMR functions in vivo.

In the study of adaptive temporal processing, the use of natural stimuli is essential in order to understand the functional consequences of the observed phenomena.

To understand the functional consequences of altered expression of ERG and ESE3, we evaluated the effects of ERG over-expression and ESE3 knock-down on cell migration using the in vitro scratch/wound healing assay and on cell survival in non-adherent conditions (anoikis assay).

To fully understand the functional consequences of genetic variation, we have to integrate across these levels of information.

To understand the functional consequences of the SNVs we annotated these variants using SnpEff (Table  2) [ 17].

Due to the importance of microbial and host derived metabolites for intestinal health, it is important to better understand the functional consequences of microbial dysbiosis.

However, more in-depth analysis of both LRRK2 and ULK1 SNPs must be performed to fully understand the functional consequence in CD pathogenesis.

To further understand the functional consequence of the RRM2B mutations identified, we mapped the positions of the mutated amino acids on the tertiary p53R2 structure (Smith et al., 2009) (Fig. 5).

To understand the functional consequence of EEA1 monoubiquitination, we took advantage of the observation that in-frame fusion of ubiquitin to a protein often mimics endogenously generated mono-ubiquitinated protein [ 24, 25].

To understand the functional consequence of SNPs in the Pgl and Lac genomes, we identified proteins that are significantly enriched (false discovery rate < 0.1) in substitutions in their structurally ordered regions (Additional file 5: Table S5A, B).

We have yet to fully understand, however, the functional consequences of its increased expression.