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Further studies on the genetic contribution to migraine are necessary to understand the complex pathophysiology of this disease.
Clinical follow-up will be of great benefit to patients and their families but will be less useful in generating the kind of data that will allow us to better understand the complex pathophysiology in this diverse group of patients[ 4].
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Furthermore, this antiquated, non-relational system of data collection and presentation limits our ability to understand the complex relationship between variables and precludes longitudinal analysis of trends and developing patient pathophysiology.
It is encouraging, however, that the complex pathophysiology of sepsis is becoming better understood as more studies are being reported.
The complex pathophysiology of MTrPs is not yet fully understood, but it is theoretically based on the presence and activity of MTrP [ 3, 16].
The complex pathophysiology of vascular damage in diabetes is not fully understood.
Mathematical modeling is emerging as a valuable tool to understand the pathophysiology of complex multietiological diseases such as T2DM and is proving helpful in designing better therapies.
Untangling the complex functional relationships between the various genes that are haploinsufficient in WHS is essential to fully understand the underlying pathophysiology of this condition.
A better neurobiological insight into habituation mechanisms would help understand the interictal pathophysiology of migraine.
The biological responsiveness was measured using both conventional immunological assays as in the previously published literature, and whole genome expression profiling, in an attempt to understand the pathophysiology of the illness in terms of the complex biological networks.
Further research on this complex and multifactor/polygenic type 2 diabetes requires collation of all the known candidate genes and related information to understand the complete molecular pathophysiology of the disease.
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