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In the past, computational approaches were not applied to understand the combinatorial interplay of TFs acting in concert after treatment of human hepatocyte cultures with Aroclor 1254.
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To better understand the combinatorial effect of multiple gene transcripts on IgE regulation we performed canonical pathway analyses.
It is necessary to understand the combinatorial relationships between TFs given the high co-localization of TFs in the promoter regions.
To understand the combinatorial role of multiple regulatory regions to produce the highly specific pattern of INO expression we have investigated promoter regions of this gene in Arabidopsis.
A major challenge for systems biology is to understand the combinatorial regulation in signaling cascades and transcription initiation mechanisms that underlie complex cellular behaviors.
We consider here a model of single-gene stochastic expression that can represent arbitrary prokaryotic or eukaryotic promoters, based on the combinatorial interplay between molecules and epigenetic factors, including energy-dependent remodeling and enzymatic activities.
Compartmental PK/PD modeling simulations can be very helpful to better understand the complex interplay of deposition, clearance, dissolution and absorption.
In addition, it is also important to understand the tangled interplay that personal disappointments, traumatic events and ideology can have on such an individual.
Clearly, more studies are needed to understand the complex interplay between TRPV1 and the CB1 receptor in the nervous system.
Clearly, we are only beginning to understand the complicated interplay between environment and health.
Building networks of interactions between these genes provides a means to understand the complex interplay in the brain during neurodegeneration.
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