We have a good, if not complete, understanding of how synapses work, but understand little of how membrane traffic and the cytoskeleton work together to establish and maintain the extraordinary cellular architecture of the brain.
There are other major challenges involved in translating WGS into the clinic, including questions of mutation penetrance, better understanding of the genes about which we understand little, and how to counsel patients who test negative or positive for an identified familial mutation in one of the less well understood genes (CHEK2, PALB2 or RAD51C are good examples of this).
"I understand," Little Horse said.
They understand little of each other's ways.
Most have never been to Yemen before, understand little Arabic and have never worn a veil.
First, most people still feel they understand little about the roots of the 2008 crash.
My father understood this cruel twist, though at times he seemed to understand little else.
They share a room and are study mates, since their parents understand little English.
Their English is very Scottish, and I understand little of it.
We also hear (but understand little) about how Mr. Greer and others commune with aliens through a kind of meditation.
In terms that Richard Hoover might understand, "Little Miss Sunshine," a slight but charming movie, is a modest winner.
