This new mechanism is likely to play a critical role in the regulation of the formation of neural circuits and may help understand dysfunctions related to conditions under which alterations of the excitation/inhibition balance may occur.
Whilst the pathophysiological mechanisms leading to disease are poorly understood, dysfunction of the insulin-producing pancreatic beta-cells is key event for disease development.
Whereas distress is primarily a manifestation of a stress-coping problem, depression and anxiety are triggered or aggravated by still poorly understood dysfunctions of mood and anxiety regulation systems [ 11].
Although underlying molecular mechanisms are poorly understood, dysfunctions in 5-HT reuptake (5-HT transporter, 5-HTT), catabolism (MAO-A), and postsynaptic receptors (5-HT2A and 5-HT2C) are thought to disrupt PFC top-down control over the amygdala, resulting in emotional dysregulation (1,77 83).
Our lab develops new biochemical and biophysical techniques to investigate these compartments and to understand their dysfunction in human disease.
This study was designed to understand muscular dysfunction in patients with episodic (ETTH) and chronic TTH (CTTH) using surface electromyography analysis (SEMG).
Topics include brain modeling over multiple scales and levels of analysis, and the use of these models to understand psychiatric dysfunction, its remediation, and the sustenance of healthy cognition through the lifespan.
The first half of director Frederic Wake-Walker's production does little to clarify the confusion, but in the second part things begin to make sense, and, as the house (designed by Antony McDonald) gradually falls apart before our eyes, we understand the dysfunction that underlies the story.
There may be fundamental implications for how we understand immunological dysfunction observed in modern humans.
This is particularly true with respect to cerebral brain because of the recent interest in the effects of cerebral flow and efforts to understand neurologic dysfunction.
