Although overlap was observed between the different ETS classes, most of the peaks observed were specific for a given factor, underscoring the specificity of the ETS-family members.
The interaction of redADan peptide and lens crystallins are very specific when compared with another chaperone, HSP-70, underscoring the specificity of the pathogenic form of Danish dementia peptide, redADan, for the early onset of cataract in this disease.
Notably, no association was observed with the DNA ligase complex, XRCC4/LigIV (Fig. 2a), involved in the repair of DSBs by NHEJ repair, or LigI (Supplementary Fig. 4c), involved in DNA replication and replication-associated excision repair, underscoring the specificity of association of FUS with XRCC1/LigIII.
No evidence of increased excitability was detected in mice carrying null mutations of the gamma isoform of protein kinase C, underscoring the specificity of the effect of CaMK.
Vasodilation in response to acetylcholine, vasoconstriction in response to phenylephrine, and passive mechanical compliance did not differ between genotypes, greatly underscoring the specificity of the above trpv4-dependent phenotype for physiologically relevant shear stress.
Of note, hypoxia-induced HIF-1α levels were comparable in Hep3B and Hep3B-GD3 cells (Figure 3A), and consistent with this outcome, no changes in the mRNA of HIF-dependent genes (pyruvate dehydrogenase kinase 1, PDK1; and vascular endothelial growth factor, VEGF) were detected (data not shown), underscoring the specificity of the inhibition of NF-κB activation by GD3.
As higher concentrations were selectively attained by fibroblast-specific deletion of Sod2 (Treiber et al, 2011), these data underscore the specificity of our model and a previously unreported critical role of increased concentrations in suppressing the IGF-1/AKT axis in vivo.
Titration assays in which T. harzianum DNA from distinct strains was varied further underscored the specificity of the probes.
The blocking experiments underscored the specificity of these antibodies.
These results underscore the specificity of this technique and indicate that PAb will not induce immunosuppression.
The observation of both VSOP and erythrocytes in the lesion, but with different colours, underscores the specificity of the Prussian Blue staining method for the iron of the VSOP.
