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We found that gamma-irradiation caused the reversion of all of the trp frameshifts studied, and the plasmid pKM101 enhanced this reversion 10- to 50-fold, which underscores the requirement for the UmuDC proteins.
Although Fe S clusters may assemble spontaneously from elemental iron and sulfur in protein-free systems, the potential toxicity of free Fe2 +, Fe3 +, and S2 − ions in aerobic environments underscores the requirement for specialized proteins to oversee the safe assembly of Fe S clusters in living cells.
This underscores the requirement of the algorithms specifically designed for analysis of scanning and electron microscopy data which must use robust workload balancing tools that are resilient to errors in algorithmic execution, as well as data transfer.
This, of course, is a challenging hypothesis that remains to be tested, and also underscores the requirement to study a larger sample of Salmonella serovars in order to identify all effectors and understand their contributions to Salmonella virulence.
The requirement of regulatory splicing factors in normal development underscores the requirement of AS and the protein isoforms generated therein in normal patterning and development.
This finding underscores the requirement for a native chromatin environment for SET transcriptional enhancement function, and further implicates H1 as a major target of SET.
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The robust and differential profiles of genomic data obtained from the approaches used herein underscore the requirement for careful anatomical refinement in CNS gene expression studies designed to understand genomic control within behaviorally-linked, but functionally isolated brain nuclei.
Together, these results underscore the requirement of XIAP's E3 ligase activity in NOD signalling.
Overall, these results underscore the requirement for direct functional testing of variants in their native gene context.
The results of these trials underscored the requirement to better access HER-2/neu expression in order to identify subgroups of patients who may benefit from HER-2/neu targeting.
Of note, however, the effect of the c.388A > G variant seems to be substrate-specific since the AUC was not altered, for example, for rosuvastatin [ 44], underscoring the requirement to perform pharmacokinetic studies for each OATP1B1 drug separately.
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CEO of Professional Science Editing for Scientists @ prosciediting.com