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The distinction between their shared responses and those of mESCs to these same growth factors underscores the development of pluripotency itself: pluripotent phenotypes range from that of mESCs (derived from the inner cell mass of the late blastocyst) to EpiSCs (derived from pre-gastrulation stages) and hESCs.
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The EMCDDA underscored the development of a deliberate "marketing" strategy for MDMA, and said that drug pushers are producing high-dose tablets in various shapes and adorned with different logos to make the product more attractive to consumers.
9, 10 The importance of cTn in the diagnosis and management of AMI was recently underscored by the development of a new "definition" of myocardial infarction.
However, since adipocytes in the mouse cannot be detected histologically until after birth, their appearance coinciding with the onset of nursing underscores the fact that the development of adipose tissue in each animal occurs at the onset of a dynamically variable nutritional environment for each individual.
This underscores the need for the development of new, more effective drugs.
The continuous burden of ACS underscores the importance of the development of new interventions and/or strategies to improve long-term outcomes.
These findings underscore the need for the development of specific guidelines.
This and other issues further underscore the need for the development of validated diagnostic criteria for AAV.
The CRH system has been extensively studied applying genetically engineered gain-and loss-of-function mouse models underscoring its importance for the development of psychiatric disorders [ 6- 8].
Our results further underscore the possibility for the development of modulators that influence channel function by altering cell surface expression densities rather than by direct action on channel biophysical parameters.
The restricted therapeutic options available to prostate cancer patients when hormonal therapy fails underscores the urgent need for the development of novel agents to tackle the castration refractory state.
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