Exact(4)
In humans, the important role of Tregs in various autoimmune diseases has been underscored by numerous seminal studies.
The importance of tightly controlling MeCP2 levels in the human nervous system has been underscored by numerous studies encompassing loss-of-function or overexpression conditions.
The beneficial effect of ABCA1wt homozygosity in humans is underscored by numerous studies demonstrating perturbed cholesterol and lipoprotein homoeostasis in individuals heterozygous for ABCA1 mutant alleles.
The importance of angiogenesis in the development and progression of prostate cancer is underscored by numerous studies evaluating microvessel density (MVD), a histological correlate of angiogenic potential, in human prostate samples.
Similar(56)
While Mitt may not be as affable in casual conversation as, say, a Bill Clinton, he has a deep love for people that is underscored by his numerous acts of personal service.
The importance of this observation is underscored by the numerous investigations into the cell cycle-dependent decrease in cyclin B/Cdc2 activity associated with Mk endomitosis (reviewed by Ravid [ 28]) and by our recent report of increased p53-DNA binding activity during Mk differentiation of the megakaryoblastic CHRF-288-11 celineine [ 21].
Critical regulatory roles performed by kinases are underscored by the occurrence of numerous cancer phenotypes when kinase activity is altered or misregulated [5].
The potential of this method is underscored by recent studies that have identified numerous genes differentially expressed after weight loss [ 11- 13].
Hardly a statement of arithmetical certainty, its provisionality – and its problematic status for its authors – is underscored by the fact that in the numerous drafts leading up to the final report the sentence appears verbatim, but with a blank space where the number was to be entered (Zuckerman and Bernal, 'Quantitative Study', 1942c and 1942d).
The importance of maintaining appropriate MYC levels for cellular homeostasis is underscored by the finding that the MYC gene is frequently over-expressed in numerous cancers including up to 80% of colon carcinomas [5], [6].
Meaning is often underscored by spellbinding moments.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com