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These findings underscore the concept of tumor angiogenic heterogeneity.
These experiments underscore the concept that modifying the tumor microenvironment can alter the organization of tumor cells and demonstrate that architecture and global chromatin organization are coupled and highly plastic.
Thus, our data underscore the concept of selective PPARα modulation when comparing WY14643 with endogenous PPARα agonists, e.g. PUFAs.
These results underscore the concept that the phosphotyrosine motif and the PRR of M2 exert intertwined actions for the optimal manipulation of the B-cell signalling machinery.
Together these observations underscore the concept that departure of the gene copy number from a homeostatic copy number, i.e., higher or lower than the average found in the population, may be an important determinant of susceptibility to diseases with a strong immunologic component.
Such decisions underscore the concept of intentional medication adherence.
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Application of high throughput genomic technologies has paved ways to gain an improved knowledge about the composition of the resident microbes and the ecosystem homeostasis and underscores the concept that dysbiosis of the flora may lead to predisposition to infection and diseases.
It has been reported that there exists an excess clustering of both CD and UC in families, which underscores the concept that the genetic architecture of these two disorders are overlapping.
Most metabolites that are required for growth on both carbon sources did not change significantly, even though transcripts and enzymatic activities required for their production changed radically, underscoring the concept of metabolic setpoints.
Finally, we show that for those genes/enzymes common to both modes of growth, expression and activity change greatly during the transition, yet metabolite concentrations remain relatively constant underscoring the concept of metabolic setpoints [24].
This finding underscores the concept of aggregation of risk markers.
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