Characterization of the Npr2 and Npr3 signalling cascade in cartilage has not been investigated previously and a greater understanding of the mechanism underpinning these pathways is needed.
Further underpinning the need for such subjective measures is the fact that physiological outcomes do not consistently correlate with self-reported health.
Kapur and McHale discuss underinvestment by government in the required skills as a factor underpinning the need for skilled migration and perpetual crisis recruitment from overseas [ 11].
Thus, data in adult patients may differ significantly from those in neonatal studies, underpinning the need for further PK studies that can be used to optimize antibiotic dosing during ECMO in this setting.
Further evaluation should also be focused on generalizability of the IPS, underpinning the need for the scale to be applied in other health care settings, especially in acute care hospitals.
Diet is also an important factor in managing this condition, underpinning the need for further evidence about choice of foods and their preparation as well as their social and cultural meanings.
Standardized tests are used to assess children who are not doing well at school, and the data from these tests are used to underpin the need for special help for these children.
"There are growing relations between Africa and China and there is need to underpin these relations with an understanding of the parties' legal systems," says Ndulo, who is also Director of the Institute for African Development at Cornell University.
However more RCTs are needed to underpin these results.
The economic reality that underpins the need for change is obvious.
This result underpins the need to consider the effects of mixtures of ENPs and organic chemicals on aquatic organisms, and the practicability of the IA and CA methods in toxicity assessment of ENPs.
