"underpinning role" is correct and usable in written English.
You can use it to refer to something that provides an essential support or foundation to something else. For example, "The teacher's underpinning role in facilitating the learning of their students is essential."
The Calderdale Framework facilitated service and task analysis to underpin role development, and the competency identification and training necessary to implement and sustain it.
Evidence points to ERβ having a significant anti-neoplastic role in MMe but the mechanisms underpinning this role remain to be elucidated.
Underpinning this role are three major issues: new ways of leveraging of intelligence, better management of the interfaces between sales and other parts of the organization; and, the integration of all processes and activities necessary to deliver superior value.
Further studies are required to elucidate the cellular basis underpinning the role of EGF in enhancing ductal cell numbers.
In present study, treatment of astrocytes with cocaine and/or gp120 led to a significant increase in JNK, p38 and ERK/MAPK pathway, thereby underpinning the role of this pathway in cocaine and gp120-mediated apoptosis.
Preliminary data indicate that the phospholipase C inhibitor U73122 partially inhibited ER stress-induced autophagy [ 67], underpinning a role for the IP3R.
To investigate the immunological mechanisms underpinning the role of IL-33 in EAU, we examined the cytokine production by the DLN and spleen cells ex vivo.
Parkin is also a candidate for dopaminergic signalling through interaction with the GPCR (G-protein-coupled receptor) Pael-R (parkin-associated endothelin receptor) [ 46, 63] and the dopamine receptor [ 64] further underpinning its role in Parkinson's disease.
In contrast, an increasing concentration of ascorbic acid, a compound that is capable of reducing ROS, leads to an enhanced aphid fecundity [ 10], further underpinning the role of ROS in plant defense towards aphids.
