The fundamental principle underpinning goal-directed therapy (GDT), better known in the field of perioperative care as "hemodynamic optimization, " is the optimization of tissue perfusion by manipulating stroke volume (SV), hemoglobin and arterial oxygen saturation (SaO2) to improve DO2 by using fluids, inotropes and red blood cells.
Underpinning this goal is our quest to answer the questions of (i) what are the cellular mechanisms regulating myometrial contractility? and (ii) what factors control the timing of onset of labour?
In fact, it is underpinned by Goal 17, a new paradigm for partnerships that promotes collaboration, efficiency, transparency, and accountability.
Of these, four patients did not require on-going rehabilitation input, six patients required short interventions that were not underpinned by goal setting and one patient refused team input.
Underpinning this broad goal are 13 targets, including ambitious new ones for improving the health and lives of women, babies, children worldwide.
There is an overall goal underpinning our wish to combine theoretical and empirical approaches to understanding uterine physiology and pathophysiology.
The same holds for countries within the British Commonwealth, as discussed by Sinnema and Aitken [15], who note the general emphasis on "competencies, pedagogy, values, student agency, partnerships and reduced prescription", which are meant to underpin the goals of "improvement, equity, future relevance and coherence" [15, p. 156].
GM's Cruise has a fleet of self-driving cars pretty much continually roving the streets of San Francisco, gathering data and improving their autonomous driving performance with the ultimate goal of underpinning future commercial self-driving products from the automaker.
Underpinning that alliance is one goal: the survival of a regime in which the al Saud family and clerics close to them are all-powerful.
