In particular, musculoskeletal pain constitutes an increasing problem in the ageing population [ 6] and is an important factor underpinning functional limitations [ 7- 9].
Whereas BOLD provides an indirect measure of neural activity related to hemodynamic changes, MEG provides a direct "electrophysiological measure" of the activity underpinning functional connectivity.
Future studies will aim to define the high-resolution structure of the SYCP3 fibre, explore the effect of SYCP2, cohesin and condensin on SYCP3 assembly, and investigate potential molecular mechanisms underpinning functional synergies between SYCP3 and double-strand break induction.
Integration of copy number and expression has provided a list of candidate dominantly acting driver genes, which can be used to underpin functional analysis that will be necessary to validate their contribution to ovarian tumorigenesis.
Although neurocognitive impairments are thought to occur before the onset of psychosis and to underpin functional impairment to be sure of the causal direction we tested all possible combinations of factors.
This study uncovers novel structural, molecular and subcellular facets underpinning the functional interplay between two major RPGR isoforms, RPGR1 19 and RPGRORF15, and RPGRIP1α1, and the differential effects of disease mutations affecting RPGR isoforms and RPGRIP1 in the subcellular targeting of RPGRIP1 among distinct cell types.
Several developmental processes react sensitively to mutations in ribosomal genes, including embryogenesis, root growth and leaf development, underpinning the functional relevance of the specific assembly of ribosomal proteins in addition to their fundamental role in translation, possibly because they are required to translate specific proteins [ 64- 66].
This suggests that the molecular and cellular machinery that underpins functional dedifferentiation is present in mammalian muscle.
Altered tissue physiology and biochemistry provide potential means for differentiating benign from malignant mesenchymal lesions and underpin functional imaging techniques [ 4].
Despite low levels of representation, the unique variation in cluster diversity observed in E. coloratus implies multiple gene duplication events within this lineage; a process that underpins functional diversification in multi-gene venom proteins [ 8, 54].
Attention-deficit/hyperactivity disorder is associated with inhibition, attention, working memory (WM), and timing deficits (2 5), underpinned by functional magnetic resonance imaging (fMRI) abnormalities in the underlying inferior frontal cortex (IFC) and dorsolateral prefrontal (DLPFC), striatal and parietal regions, and networks (2,3,6,7), which are also structurally abnormal (8 10).
